Growth factor regulation of lens development
نویسندگان
چکیده
منابع مشابه
Regulation of Lens Gap Junctions by Transforming Growth Factor Beta
Gap junction-mediated intercellular communication (GJIC) is essential for the proper function of many organs, including the lens. GJIC in lens epithelial cells is increased by FGF in a concentration-dependent process that has been linked to the intralenticular gradient of GJIC required for lens transparency. Unlike FGF, elevated levels of TGF-beta are associated with lens dysfunction. We show t...
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PURPOSE To examine the expression and function of hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), epidermal growth factor (EGF) and other growth factor-cytokine-receptor systems in lens epithelial cells. METHODS Reverse transcription-polymerase chain reaction (RT-PCR) and Northern blot analysis were used to examine the expression of messenger RNAs in primary cultured rabbit ...
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The epithelial populations found throughout the gastrointestinal tract exhibit a relatively high rate of turnover throughout postnatal life. The maintenance of normal cellularity in the setting of continuous proliferation, differentiation, and cell senescence implies the presence of exquisite regulation of cell turnover. In addition, regulatory mechanisms must provide plasticity in order to fac...
متن کاملRequirement for the c-Maf transcription factor in crystallin gene regulation and lens development.
The vertebrate lens is a tissue composed of terminally differentiated fiber cells and anterior lens epithelial cells. The abundant, preferential expression of the soluble proteins called crystallins creates a transparent, refractive index gradient in the lens. Several transcription factors such as Pax6, Sox1, and L-Maf have been shown to regulate lens development. Here we show that mice lacking...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2005
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2005.01.020